They should only be taken under medical supervision, since they carry a risk of side effects. However, high doses of niacin can cause other, more dangerous side effects, although these are rare The most harmful of these is liver damage. They can help you figure out how to reduce the chances of flush or discuss alternative treatments. Also, because there are other, more harmful side effects associated with taking these supplements, do not try self-medicating with niacin.
Niacin flush is harmless. However, the supplements can have other harmful side effects, and certain people should not take them. Taking aspirin, eating a snack, slowly increasing the dosage, or switching formulas may help you prevent niacin flush.
As mentioned above, to avoid unwanted symptoms, including flushing, some people opt for extended-release or long-acting niacin.
However, extended-release and long-acting niacin differ from immediate-release niacin and may cause different health effects. Because of this, taking long-acting niacin significantly reduced the chances of flushing However, because of the way the body breaks it down, taking long-acting niacin may have toxic effects on the liver, dependent on the dose taken Although uncommon, switching from an immediate-release niacin to a long-acting niacin or significantly increasing your dose can result in serious liver damage Plus, IHN is significantly less effective than nicotinic acid at increasing serum niacin.
IHN usually takes between hours to raise blood levels of niacin to near the optimal range Some studies suggest that peak niacin blood levels can be over times greater when supplementing with nicotinic acid compared to supplementing with IHN. Research also shows that IHN has minimal effect on blood lipid levels Absorbability differs between forms of niacin.
Some types of niacin are more effective at raising blood levels than others. If you want to take high doses of niacin for health reasons, make sure to do so under medical supervision.
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See more conditions. Products and services. Thank you for Subscribing Our Housecall e-newsletter will keep you up-to-date on the latest health information. Please try again. Something went wrong on our side, please try again. Show references Shi H, et al. NAD deficiency, congenital malformations and niacin supplementation. New England Journal of Medicine.
Schandelmaier S, et al. Niacin for primary and secondary prevention of cardiovascular events. Cochrane Database of Systematic Reviews. Accessed Aug. Micromedex 2. Niacin B3; nicotinic acid oral. Melmed S, et al. Disorders of lipid metabolism.
In: Williams Textbook of Endocrinology. Philadelphia, Pa. Pazirandeh S. Overview of water-soluble vitamins. Natural Medicines. However, pellagra is very rare and currently, it's only seen in undeveloped countries. The vast majority of people don't need to take niacin supplements because there's plenty of niacin in the foods found in a typical diet, even diets that aren't all that healthy. Nuts , legumes , eggs , poultry, beef, and seafood are all high in niacin, and it's found in smaller amounts in most other foods.
So as long as you're eating every day, you're getting plenty of niacin. Be careful if you're thinking about taking niacin for your high cholesterol levels. Even though the niacin flush is harmless, large doses of niacin can interact with many different medications.
Long-term use can cause liver damage, skin rashes, gastrointestinal problems, and elevated blood sugar. Looking to lose weight? Our nutrition guide can help you get on the right track. Sign up and get it free! National Institutes of Health. Office of Dietary Supplements. Niacin Fact Sheet for Health Professionals. Updated June 3, Randomized controlled trial of different aspirin regimens for reduction of niacin-induced flushing. Am J Health Syst Pharm.
Niacin: Chemical forms, bioavailability, and health effects. Nutr Rev. Office of Dietary Supplement. Niacin Consumer Guide. Updated July 11, Your Privacy Rights. To change or withdraw your consent choices for VerywellFit.
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